Strong evidence is showing that the trace mineral boron plays an important role in protecting men against deadly prostate cancer.1-3 Prostate cancer is the single most deadly cancer for men. As we grow older, our risk of getting prostate cancer increases and metastasis outside the prostate is “generally lethal.”1
There are many nutrients, including minerals, that can reduce the risk of getting prostate cancer. These include vitamins and minerals and other food extract nutrients. There is not, however, a single, silver bullet that causes you to be completely safe from getting prostate cancer.
The more of these nutrients that you combine and ingest, the less likely you are to become susceptible to prostate cancer. Of course, that also assumes that you are not eating foods, such as cow dairy products and grain, which encourage the growth of prostate cancer.
In recent years, there have been many studies that demonstrate that boron has been found to selectively kill prostate cancer cells while leaving healthy cells unharmed.2,4 In addition, boron has been found to lower PSA1—which was previously believed to be only a marker for prostate cancer. More recent research shows that elevated PSA is actually a causal factor in prostate cancer progression.1
Adequate boron levels are associated with a 64% reduced risk of prostate cancer,3 but obtaining protective levels of boron from food alone is difficult.5 Very little boron is to be found in food, especially if such food is not produced organically.
This means that supplementation with low-cost boron could be a lifesaver for aging males at risk of prostate cancer, in addition to other health benefits provided by this vital mineral.
Boron specifically Targets Prostate Cancer Cells
There was a 2001 study on the diet of prostate cancer patients that compared the diets of seventy-six prostate cancer patients with those of 7,651 men without prostate cancer. The study found that the men who ingested the greatest amount of boron from their diets were 64% less likely to develop prostate cancer than those who consumed the least.
There have been further studies that have confirmed similar results. One such study compared the dietary intake of boron in ninety-five prostate cancer patients with that of 8,720 healthy male controls. That study was controlled for many other factors.
They too found that men with the highest boron consumption showed a 54% lower risk of prostate cancer compared to those with the lowest intake.6. They also noted that increased dietary boron intake was associated with a decreased risk of prostate cancer. They also confirmed that the decrease was in direct proportion to the amount of boron that was consumed.
Scientists were encouraged by these epidemiological findings. The connection between dietary consumption of boron and a reduced risk for prostate cancer was clear. Scientists then set out to determine if supplementing with boron could protect against prostate cancer. Initial animal studies indicate that the answer is yes.
Researchers found that oral administration of various concentrations of a boron-containing solution substantially decreased tumor size. It also lowered levels of prostate-specific antigen or PSA—the most abundant protein synthesized in the prostate gland—suggesting a possible mechanism for these anti-cancer effects.7
In this animal model, researchers orally administered various concentrations of a boron-containing solution to test subjects and found that this resulted in a decrease in prostate tumor size by 25% to 38%. Remarkably, PSA levels dropped by an astounding 86% to 89% in the animals that received boron.7
These findings suggested that supplemental boron may have both preventive and therapeutic effects—helping both to shrink prostate tumors and to decrease levels of PSA.
New Ways To Protect Against Prostate Cancer
Prostate cancer and particularly metastasised prostate cancer is the greatest scourge of men’s health. So discovering the link between supplementation of boron and the reduction of PSA levels was very exciting, as it provides a simple method of preventing prostate cancer.
Previously, PSA was thought to be primarily a blood indicator of prostate cancer, infection or inflammation. It is now understood that PSA levels play a critical role in the progression and metastasis of prostate cancer. 1,8-11
Scientists now believe that elevated PSA can break down the protein surrounding the cells. The breakdown of these cellular barriers by excess PSA may be what enables prostate cancer cells to more readily invade healthy tissue and metastasis beyond the prostate gland, with potentially lethal consequences.8
This remarkable finding provides further understanding as to how we may prevent or slow down prostate cancer by reducing PSA levels.
Published results from studies suggest that higher intake of boron-containing compounds can inhibit PSA activity7 and lower the risk of prostate cancer.12
Using Boron For Treatment
A 2014 study published in Tumour Biology, revealed that a compound containing boron induced apoptosis, or cell death, in prostate cancer cells. They concluded that the boron could be an important agent for the treatment of prostate cancer 2
From all the studies on boron and its effects on prostate cancer and metastasis, it becomes increasingly clear that it is beneficial to supplement it. That is preferable to relying on the small and very variable amounts of boron available in plant foods. So boron is an important component of any strategy to prevent prostate cancer and maintain optimal PSA levels.
Indeed, newly published studies suggest that boron delivers another important layer of protection against prostate cancer metastasis. Boron is concentrated in the bone.
In fact, emerging studies now suggest that boron delivers another layer of protection against the symptoms of this prostate cancer—in the bone.
Boron For Bone Health
The most deadly danger in prostate cancer is its ability to spread to the bone. Bone is the initial and main site for about 80% of all prostate cancer metastases.15 They occur most commonly in the spine, pelvis, ribs, skull, and proximal femur.16
These bone metastases induce significant skeletal, fractures, anemia, and pain—and are a major cause of morbidity and mortality.17 Prostate cancer has been described as “generally lethal once it has escaped the confines of the prostate gland.”1. Sad to say, the median survival of patients after prostate cancer has spread to the bone is only forty months.16
Boron’s remarkably targeted capacity to inhibit the spread of prostate cancer cells while sparing normal cells4 may have the same targeted effect against prostate cancer cells that have migrated to the bone.
With boron supplementation, this cytotoxic effect—combined with boron’s potential to help prevent prostate cancer from occurring in the first place—could reduce the current 28,000 American deaths from this disease every year.1
Weak bones—whether the result of cancer or aging—can lead to pain, fracture, and disability. Boron plays an integral part in bone metabolism. It supports the functions of calcium, magnesium, and vitamin D, all of which are crucial to promoting dense, healthy bone tissue.5,18-20
Another study showed that when animals were fed a diet deficient in vitamin D, increasing their dietary intake of boron helped support optimal calcium absorption—demonstrating that boron promotes optimal mineral balance and ensures healthy calcium utilization.20
Your Own Risk Of Being Deficient In Boron
Most men are deficient in boron. That is partly because it is only present in variable and small amounts in plant foods. And that situation is worsening through intensive farming, which is depleting the soil of minerals.
As an example, apples are considered to be a good source. To gain the minimum of 3mg of boron daily you would need to eat 2.4lb of apples.
With the Standard American diet (SAD), men do not typically eat enough fruits and vegetables, so they are likely to be deficient in boron. Autopsy evidence shows that prostate cancer is histologically present in up to 34% of men aged between 40 and 49.
That rises to up to 70% in men aged 80 or older. So it is no exaggeration to suggest that prostate cancer is omnipresent in the aging man. 38-40
Helps Reduce Inflammatory Conditions
In addition to the benefits of reducing prostate cancer risks, boron has significant anti-inflammatory capabilities. About 52 million Americans suffer from some form of arthritis.22. It is very fortunate that boron inhibits pro-inflammatory factors which contribute to the development of arthritis.21,23
In a double-blind study in people with severe osteoarthritis, a study found that in those who completed the trial, 71% of those taking boron improved, while only 10% of those taking placebo improved. No side effects were observed.25
One study even found that boron can reduce the pain associated with osteoarthritis. For the study, 50% of osteoarthritis patients who received 6mg of boron daily reported less pain from movement, while only 10% given a placebo experienced similar improvement.25 This was likely due to a reduced production of pain-provoking inflammatory mediators.27-29
These study results indicate that adequate boron intake confers powerful protection against osteoarthritis.
The supplementation of boron has been shown to be extremely beneficial in reducing the risk of prostate cancer and metastasis. Boron can kill prostate cancer cells without harming healthy prostate cells.
Studies have shown that boron lowers PSA levels, which may help prevent or control the spread of prostate cancer, both within the prostate and metastasis into the bones. In addition, it provides support for healthy bones and joints.
It is clear that there are a great deal of benefits in supplementing with boron. However, despite all this compelling evidence, very few supplements for the prostate contain boron. One exception to the general rule is my Total Health for the Prostate supplement.
Not only does Total Health for the Prostate contain fifteen (mainly chelated) minerals plus a full complement of vitamins, it also contains a number of important nutrients that protect against inflammation and cancer.
And from today, my new and improved Total Health formula will contain even more boron than before! If you would like to read more about the Total health supplement for the prostate, please click here.
I Wish You Good Health,
- LeBeau AM, Kostova M, Craik CS, Denmeade SR. Prostate-specific antigen: an overlooked candidate for the targeted treatment and selective imaging of prostate cancer. Biol Chem. 2010 Apr;391(4):333-43.
- Korkmaz M, Avci CB, Gunduz C, Aygunes D, Erbaykent-Tepedelen B. Disodium pentaborate decahydrate (DPD) induced apoptosis by decreasing hTERT enzyme activity and disrupting F-actin organization of prostate cancer cells. Tumour Biol. 2014 Feb;35(2):1531-8.
- Zhang Z-F, Winton MI, Rainey C, et al. Boron is associated with decreased risk of human prostate cancer. FASEB J. 2001;15:A1089.
- Barranco WT, Eckhert CD. Boric acid inhibits human prostate cancer cell proliferation. Cancer Lett. 2004 Dec 8;216(1):21-9.
- Schaafsma A, de Vries PJ, Saris WH. Delay of natural bone loss by higher intakes of specific minerals and vitamins. Crit Rev Food Sci Nutr. 2001 May;41(4):225-49.
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- Gallardo-Williams MT, Chapin RE, King PE, et al. Boron supplementation inhibits the growth and local expression of IGF-1 in human prostate adenocarcinoma (LNCaP) tumors in nude mice. Toxicol Pathol. 2004 Jan-Feb;32(1):73-8.
- Webber MM, Waghray A, Bello D. Prostate-specific antigen, a serine protease, facilitates human prostate cancer cell invasion. Clin Cancer Res. 1995 Oct;1(10):1089-94.
- Gallardo-Williams MT, Maronpot RR, Wine RN, et al. Inhibition of the enzymatic activity of prostate-specific antigen by boric acid and 3-nitrophenyl boronic acid. Prostate. 2003 Jan 1;54(1):44-9.
- Cohen P, Graves HC, Peehl DM, et al. Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab. 1992 Oct;75(4):1046-53.
- Cohen P, Peehl DM, Graves HC, et al. Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease. J Endocrinol. 1994 Sep;142(3):407-15.
- Henderson K, Stella SL, Kobylewski S, Eckhert CD. Receptor activated Ca(2+) release is inhibited by boric acid in prostate cancer cells. PLOS One. 2009;4(6):e6009.
- Chang SS. Overview of prostate-specific membrane antigen. Rev Urol. 2004;6(Suppl 10):S13-8.
- El-Zaria ME, Genady AR, Janzen N, Petlura CI, Beckford VDR, Valliant JF. Preparation and evaluation of carborane-derived inhibitors of prostate specific membrane antigen (PSMA). Dalton Trans. 2014 Apr 7;43(13):4950-61.
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- Jimenez-Andrade JM, Mantyh WG, Bloom AP, Ferng AS, Geffre CP, Mantyh PW. Bone cancer pain. Ann N Y Acad Sci. 2010 Jun;1198:173-81.
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- Scorei ID, Scorei RI. Calcium fructoborate helps control inflammation associated with diminished bone health. Biol Trace Elem Res. 2013 Dec;155(3):315-21.
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