5 Devastating Side Effects of a Prostate Biopsy

by Ben Ong
Reading Time: 7 minutes
side effects of a prostate biopsy

Prostate cancer is the most common cancer in men. It affects one in three American men during their life time. By the age of 50, many men start to get screened, usually undergoing a PSA test. During this screening, if it seems that an individual has the possibility of cancer, it’s common medical practice to recommend a biopsy. This is to confirm whether cancer is present.


But, mounting evidence suggests that biopsies has many dangerous and unpleasant side effects.


This article will discuss the safety of undergoing a prostate biopsy and the 5 side effects that could affect your quality of life.

What Is A Prostate Biopsy?

A prostate biopsy is a procedure used to detect prostate cancer. Small samples of the prostate are removed and then observed under the microscope.


A urologist or surgeon usually performs this procedure. They will look at the prostate cell samples to see if they are cancerous. Cancer cells are often irregular in size and shape, and exhibit aggressive growth.


Doctors usually recommend a biopsy of your prostate gland based on certain findings. One is if your prostate-specific antigen (PSA) blood test results are higher than normal for your age. Another is if your doctor detects signs of a prostate problem during your digital rectal exam (DRE).
Although the PSA and DRE or show a possible problem with your prostate, a biopsy is needed to confirm if it’s cancer.


A prostate biopsy involves collecting minute samples of the prostate gland. The doctor passes a needle through the rectal wall or makes a small cut in the area between the anus and rectum to obtain the samples. A CT or MRI scan is also used to guide them through the procedure.


Prostate biopsy takes about 10 minutes and is usually done in the doctor’s office. The samples will be sent to a lab, and will be looked at under a microscope to see if they contain cancer cells.


If cancer is detected, it will also be assigned a grade. The results are available after 1 to 3 days, but it can sometimes take longer. 

Types of Prostate Biopsy

A prostate biopsy may be done in several different ways:

Transrectal method

This is done through the rectum and is the most common.

Perineal method

This is done through the skin between the scrotum and the rectum.

Transurethral method

This is done through the urethra using a cystoscope (a flexible tube and viewing device).

Transperineal biopsy

Unlike the TRUS Guided Biopsy, this is where the doctor inserts the needle into the prostate through the skin between the testicles and the anus. This area is called the perineum. The needle is inserted through a template or grid.

Although one of the most common procedures for detecting prostate cancer, biopsies carry many potential risks and side effects:

1) Bleeding

side effects of a prostate biopsy

Just like any invasive procedure, bleeding will occur. It’s normal to see a small amount of blood in your semen or urine for about 2 weeks. However, it becomes a major problem if bleeding takes a longer time or if it gets worse.

One study reviewed the safety of the transrectal ultrasound guided needle biopsy. It found that 58 patients (63%) experienced haematuria and experienced rectal bleeding 23 patients (25%). Severe rectal bleeding is an uncommon complication yet in some instances can be life-threatening. So, both patients and practitioners should be aware of the risks.

2) Pain

After the biopsy it is highly common for patients to experience discomfort and pain. This usually only lasts for a few days after the procedure, but the degree of pain will vary for each individual. While some may find it very painful, other people only report a slight discomfort. This is because of the injury caused by the needle on your prostate cells.

side effects of a prostate biopsy

A prospective cohort study measured the short-term outcomes of men undergoing a prostate biopsy. The participants were asked to complete a questionnaire, measuring the frequency and effect of symptoms related to pain, infection and bleeding.

The results found that pain was reported by 429/984 (43.6%), fever by 172/985 (17.5%), haematuria (blood in urine) by 642/976 (65.8%), hematochezia (anual bleeding) by 356/967 (36.8%), and haemoejaculate (the presence of blood in a man’s ejaculate) by 605/653 (92.6%) men during the 35 days after biopsy. Although the researchers concluded that prostate biopsy is well tolerated by most men, it is associated with significant symptoms in a minority and affects attitudes to repeat biopsy.

Pain is a very important symptom to monitor. Worsening and persistent pain may indicate a bigger problem. If this is the case, you need to see your doctor for a follow-up.

3) Infection

side effects of a prostate biopsy

A further risk of having a prostate biopsy is infection. Surgeons will usually prescribe strong antibiotics to reduce the risk of infection. However, infection almost always occurs. Research indicates that resistance to antibiotics is increasing the likelihood. In some cases, the result of the infection is that there is long-term sexual dysfunction.

Occasionally, these infections can turn into life-threatening sepsis. This is as needles used to detect cancer are passed through the rectum. As a result, if the needles transport bacteria from the bowel into the prostate, bladder and the bloodstream, infection can occur.

A study by John Hopkins researchers was published in The Journal of Urology. It found that men hospitalized as a result of a biopsy-related infection had a 12-fold greater chance of dying than those who did not undergo a biopsy.

4) Acute Urine Retention

About 1 in 50 men who have undergone prostate biopsy experience acute urine retention. The procedure does injure the prostate gland, causing it to swell. And this makes it hard for you to pass urine.

side effects of a prostate biopsy

If the prostate is particularly enlarged (>50mL) or the man has pre‐existing risk factors, e.g. a poor flow, a high residual volume or previous urinary retention, then the risks of biopsy‐induced urinary retention are significant. Acute urine retention is a medical emergency, and you need to seek help at once. The doctor often inserts a catheter to drain the retained urine, and it will take a few days for you to recover.

5) Sexual Problems

Several studies have found that men develop Erectile Dysfunction after having a prostate biopsy. In 2015, BJUI International published a study involving 220 men who underwent transrectal prostate biopsy.

Overall the researchers reported an increased risk of temporary ED after biopsy of approximately 5%. While this happens rarely and should improve over time, the study concluded that the effects of TRUS‐guided prostate biopsy on ED have probably been underestimated.

It is important to be aware of these side effects so patients can be appropriately counselled.  If sexual problems persist, you should consult your doctor.

Are Prostate Biopsies Safe?

One of the main issues with prostate cancer screening tests is that they can lead to misdiagnosis and as result, overtreatment. Even if you take many samples, a biopsy can still sometimes miss a cancer. This occurs if none of the biopsy needles pass through the rights areas. Thus, the biopsy will have a false-negative result. In fact, one study found that biopsies detected only 67.8% of prostate cancers.

Alternatives To Prostate Biopsies

Doctors have long relied on biopsies to determine prostate cancer. And biopsies are proven to be dangerous. Often, a prostate biopsy finds traces of low-grade cancer that don’t need to be treated.

MRI

But in recent years, doctors have found out that new imaging studies like high-resolution MRI and ultrasound can be alternatives to prostate biopsy.

They have proven to be very accurate and safe. A multi-parametric MRI or a color Doppler ultrasound has a 95 to 98% chance of determining the location and grade of prostate cancer cells.

According to the Diagnostic Center for Disease, an MRI scan predicts and confirms the presence of prostate cancer more frequently than a biopsy. A hi-res MRI features the most sensitive and specific imaging modality that allows it to produce a very clear picture of the entire prostate and pelvic region.

Experts claim that this is a quantum leap from the blind biopsy approach. It will minimize the need for biopsies, and could potentially save millions of dollars for the healthcare industry.  

PCA3 Test

The PCA3 test is another alternative. PCA3 stands for “Prostate Cancer gene 3”, a protein that is produced by prostate cancer cells at much higher levels. PCA3 leaks into the urine when the prostate gland is stimulated.

Unlike the PSA test, a high PCA3 test can only result from cancer – not from an enlarged prostate, inflamed prostate or other non-cancerous prostate problem.

For this test, you need to undergo a DRE. This will stimulate PCA3 to leak into the urine. A urine sample is then collected and sent to the lab. It takes about 1-2 weeks to get the results. The higher the PCA3 score, the more likely you have prostate cancer.

This test is also used to determine the effectiveness of cancer treatment. The higher the score, the more aggressive is the prostate cancer.


Prior to having a biopsy, do your research. Do not blindly agree to a procedure without being aware of the possible life changing side effects it could have. There are alternatives to a prostate biopsy, like MRI and the PCA3 test. These methods are non-invasive and accurate. Plus, they don’t have the negative side effects that result from a prostate biopsy.

5 Devastating Side Effects of a Prostate Biopsy
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About Ben Ong

Ben Ong is a best-selling author and widely regarded as one of the world’s leading experts on natural treatments for metabolic conditions such as prostate disease and type 2 diabetes. He founded Ben’s Natural Health and has worked for over 20 years providing a range of high quality, clinically effective, all-natural supplements for BPH, high PSA, high blood sugar, sexual dysfunction, and others.
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  1. Arthur cambridge

    Well my biopsy was was awful ended up in the hospital for 4 days. Night seeets chiller massive headache. Wow is all I can say!! Chose right away for prostrate surgery get that stuff out of me!

  2. Stefan Kowalski

    Could you get blood clots after prostrate biopsy

    • Ben Ong

      Hi Stefan, we discuss the possible effects of a prostate biopsy in further detail in this article=> http://www.bensprostate.com/prostate-biopsy-safe/ . If you are experiencing severe bleeding or are passing a lot of blood clots, then you need to contact your doctor right away.

  3. Frank Lindsey

    Hello. I just now joined this program. I am 74 y/o with a PSA results of 6.2. Of course my 32 y/o Urologist recommends that I immediately get a biopsy. I suggested a repeat screening. This was not his wish. I’ve read that this results is considered normal for a man my age experiencing NO other symptoms. Can you offer any feedback or recommendations?

    • Ben Ong

      Hi Frank, nearly 70% of men that are offered a biopsy will have no sign of prostate cancer. Therefore, the PSA test can lead to having an unnecessary invasive procedure that can cause a serious infection. You should have an MRi scan instead because it is a much safer procedure. The MRI scan would tell you if you have any prostate cancer which has spread to nearby organs or bones. It will also show up any shadows within your prostate, which could be showing early-stage cancer but the shadows could also be something else. So an MRi is only an indication but if there is no sign of prostate cancer, that would be definitive and could spare you from any further expenses. If you would like to discuss this further detail please feel free to get in touch with our team via [email protected] or alternatively, if you wish to speak to someone you can call our toll free number 1-888-868-3554 in the US and +44 (0) 845 423 8877 in the UK. The Ben’s Natural Health Team.

  4. Dave A

    I am 74 years old and have a PSA of 7 and had an MRI done which showed a lesion 2x1x1.2 cm rated a PI-RADS 5. The Dr. said it was 95% chance of being cancerous. They recommend a targeted biopsy. I am inclined not to have it since it can be assumed to be cancer so why risk the side effects of a biopsy. Also it may spread as a result of a biopsy. What is your opinion?

    • Ben Ong

      Hi Dave, very sorry to hear this. Could you please get in touch with our support team via our toll free number 1-888-868-3554 or by emailing [email protected] so that we can discuss this with you in further detail. Best of health. The Ben’s Natural Health Team.

  5. bob moore

    ive had 2 biopsy taken one in 2009 and 1 in 2015 i havnt taken any tablets or injection for 4 months and before original psa was 109 last blood count was 0.3

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